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Davids Sensitive + Whitening natural peppermint toothpaste tube displayed on a white textured surface.

answering your common questions about hydroxyapatite, the hero ingredient

Hydroxyapatite is generating a wave of interest in the world of oral care, and rightfully so. But naturally, this interest comes with a lot of questions. Is hydroxyapatite safe? Does it really work? How do I know which product is the right fit?

We completely understand and appreciate the curiosity. After all, nano hydroxyapatite is still new to many people. To address some of your questions and ease some of your doubts, we're answering these questions head on and citing scientific studies along the way.

key takeaways

  • what is nano hydroxyapatite? It is a nano sized form of hydroxyapatite, the same mineral that makes up about 97% of natural enamel.
  • Davids uses rod shaped nano hydroxyapatite particles in Hydroxi™ formulas to help bind to enamel and support remineralization.
  • is hydroxyapatite safe? Hydroxyapatite is biocompatible and already found naturally in teeth and bones.
  • what is nano hydroxyapatite toothpaste? It is toothpaste made with nano hydroxyapatite to support enamel health, sensitive teeth, and a smoother tooth surface.

is hydroxyapatite safe?

The short answer to this question is yes. Hydroxyapatite itself is a biocompatible mineral that already exists naturally in your body. In fact, it makes up roughly 97% of your tooth's outer surface.

Hydroxyapatite toothpaste can be a good fit when formulated intentionally and carefully. When we say that the safety of hydroxyapatite toothpaste depends on its formulation, we mean several things.

So what is nano hydroxyapatite compared with other forms of the same material? Nano hydroxyapatite particles are small enough to interact with the tooth surface and help support enamel health. Davids uses rod shaped nano hydroxyapatite particles in Hydroxi™ formulas to support remineralization and sensitive teeth.

Diligent user and lab testing matters. How can you evaluate toothpaste without lab testing? Davids submitted samples of top competing sensitive toothpastes to one of the largest third party laboratories that specialize in oral care product testing. Davids performed strongly by helping fill exposed dentin tubules to support sensitive teeth.

The other ingredients in the toothpaste matter. Hydroxyapatite is an important ingredient, but the rest of the formula matters too. At Davids, we use premium ingredients in our formula that took over 4 years to perfect.

does the % of hydroxyapatite in hydroxyapatite toothpaste matter?

The short answer is that it's not that simple.

You'll find that some functional dentists recommend looking for hydroxyapatite toothpaste with "at least X% of hydroxyapatite" in the formula.

But the truth is, the performance of hydroxyapatite toothpaste depends more on quality than quantity of the hero ingredient. It also depends on the type and grade of material being used, the particle shape, the supporting ingredients, and the full formula.

While some competitors use cheaply sourced, less consistent versions of nano hydroxyapatite, Davids only uses nanoXIM from Fluidinova. nanoXIM is widely regarded as the gold standard in nHA with the most scientific research, reviews, and regulatory approvals. It is the most effective, efficient, consistent, and safest ingredient you can use.

what percentage of Davids Sensitive+Whitening Nano Hydroxyapatite Toothpaste is actually nano hydroxyapatite?

We do not disclose % as this is proprietary information to our formulation, and it does not provide meaningful info on how the toothpaste actually performs. The third party lab testing we did shows that Davids performed strongly by helping fill exposed dentin tubules to support sensitive teeth. Please visit our website to see photos as part of our lab results that show the performance of our formulation.

If you are asking what is nano hydroxyapatite toothpaste, the full answer goes beyond a single percentage. It is a toothpaste formula that uses nano hydroxyapatite as part of a broader ingredient system designed to clean, polish, and support enamel health.

what's the difference between hydroxyapatite, nano hydroxyapatite, and micro hydroxyapatite?

Hydroxyapatite is the name of the mineral itself, and for those interested, its chemical formula is Ca10(PO4)6(OH)2. Hydroxyapatite makes up roughly 97% of your enamel, and hydroxyapatite like compounds make up roughly 65% of your bones.

what is nano hydroxyapatite in simple terms? Nano hydroxyapatite is hydroxyapatite with very small particle sizes. Scientific studies suggest that these nanoparticles can bind to the proteins in your saliva and, in turn, the surface of your enamel. This allows nano hydroxyapatite to help strengthen enamel, support remineralization, and help fill exposed dentin tubules.

Micro hydroxyapatite particles are much larger than nano hydroxyapatite particles. They may not interact with the tooth surface in the same way because of their larger particle size.

While nano hydroxyapatite is often preferred in toothpaste formulas, Dr. B of Ask the Dentist confirms that there are no safety concerns regarding the absorption of particles based on size. In other words, both micro and nanoparticles can be absorbed by your cells, which is not an issue because hydroxyapatite is biocompatible.

For more information, we recommend listening to his podcast episode, "Does Size Matter?"

how long does it take for hydroxyapatite toothpaste to support sensitive teeth?

The podcast in the previous section reveals that nano hydroxyapatite toothpaste is an increasingly popular option for sensitive teeth and can provide noticeable support after 2 to 4 weeks of regular use.

Our third party lab testing revealed that our unique formula was effective in bonding to enamel and helping fill exposed dentin tubules to support sensitive teeth after just five days of twice daily brushing.

can hydroxyapatite help reverse cavities?

No toothpaste can claim to reverse cavities or prevent new ones from forming unless that claim is specifically supported and appropriate for the product. Hydroxyapatite can support enamel health, support remineralization, and help strengthen existing enamel as part of a consistent brushing routine.

Check out this article with studies compiled by Mark Burhenne, DDS of Ask the Dentist and Jacqueline Carcaramo, RDH. Many of the studies discuss hydroxyapatite and its role in supporting enamel health.

how do I know which hydroxyapatite toothpaste is right for me?

We may be biased, but our third party lab testing results are not.

We submitted samples of top competing sensitive toothpastes to one of the largest and most trusted third party laboratories that specialize in oral care product testing to see how well Davids Sensitive+Whitening Nano Hydroxyapatite toothpaste would perform.

All numerical and photo evidence from the lab results showed that Davids performed strongly by helping fill exposed dentin tubules and supporting sensitive teeth. In other words, science helps us feel confident in Davids Hydroxi™ formula.

Competing products include Apagard Premio, Boka, Colgate Sensitive, Risewell, Sensodyne Pronamel, and Toms Sensitive.

We also use nanoXIM from Fluidinova, which is the industry leader and the gold standard in nano hydroxyapatite with more scientific research, data, and review than any other ingredient.

how can I use hydroxyapatite best in my oral care routine?

Here are a few tips:

  • Brush at least twice daily with Davids Sensitive+Whitening Nano Hydroxyapatite Toothpaste.
  • Start right away, even if you don't have sensitivity. Like most ingredients, hydroxyapatite works best with consistent use.
  • Support your oral care routine by eating a nutrient dense diet that supports strong, healthy teeth.
  • Elevate your oral care routine with daily flossing and tongue scraping.
  • Stay consistent. One of the best ways to do this is to take note of how your teeth feel once you start using nano hydroxyapatite toothpaste.

hydroxyapatite FAQs

what is nano hydroxyapatite?

Nano hydroxyapatite is a nano sized form of hydroxyapatite, the mineral that makes up about 97% of natural enamel. In toothpaste, it helps bind to enamel, supports remineralization, and helps fill microscopic fissures, irregularities, channels, and cracks in enamel.

is hydroxyapatite safe for daily brushing?

Hydroxyapatite is biocompatible and already exists naturally in teeth and bones. When asking is hydroxyapatite safe, it is also important to look at the full toothpaste formula, ingredient quality, and product testing.

what is nano hydroxyapatite toothpaste used for?

Nano hydroxyapatite toothpaste is used to support enamel health, support remineralization, and help support sensitive teeth. Davids Hydroxi™ formulas use rod shaped nano hydroxyapatite particles in a fluoride free, SLS free formula made without artificial colors, flavors, or preservatives.

why does Davids use nano hydroxyapatite?

Davids uses nano hydroxyapatite in Hydroxi™ formulas because it helps support enamel health, supports sensitive teeth, and contributes to a smoother tooth surface. For anyone asking what is nano hydroxyapatite, this is why it has become an important ingredient in oral care.

how do I choose a nano hydroxyapatite toothpaste?

Look beyond the ingredient name alone. A thoughtful formula should include quality ingredients, a gentle brushing feel, and clear product standards. Davids Hydroxi™ toothpaste is fluoride free, SLS free, and made without artificial colors, flavors, or preservatives.

try it out yourself

You can continue to read our reviews and results as much as you want, but the proof is in the paste. Try out our hydroxyapatite toothpaste for yourself.

buy nano hydroxyapatite premium toothpaste / peppermint now

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About Author

Andrew Talarzyk is a marketing leader at Davids Toothpaste, where he helps bring the brand’s clean, science-forward approach to oral care into sharper focus for consumers, retailers, and media partners. As Senior Manager of Marketing, Andrew supports a brand built on the belief that toothpaste can be both high-performing and thoughtfully made, combining naturally sourced and naturally derived ingredients with modern dental science.

Through his work with Davids, Andrew helps communicate the company’s broader mission: creating oral care products that prioritize ingredient transparency, sustainability, and everyday performance without relying on harsh chemicals, artificial flavors, colors, or preservatives. His leadership aligns closely with Davids’ position as an innovator in the nano hydroxyapatite space, particularly through the brand’s Hydroxi™ formulas. 

Hydroxyapatite is especially compelling because it mirrors a mineral naturally found in teeth and is used in Davids products to support enamel health, help smooth micro-imperfections, and provide sensitivity support.

Andrew’s value as a spokesperson lies in his ability to connect product innovation with a broader consumer shift toward cleaner, more intentional personal care. He represents Davids as a brand that is not simply following the natural oral care category, but helping define where it goes next: toward formulas that are effective, transparent, sustainability-minded, and grounded in a more informed understanding of what people want from the products they use every day.