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answering your common questions about hydroxyapatite, our newest hero ingredient

answering your common questions about hydroxyapatite, our newest hero ingredient

Hydroxyapatite is generating a wave of excitement in the world of oral care, and rightfully so. But naturally, this wave of excitement comes with a lot of questions. Is it safe? Does it really work? How do I know which product is the best?

We completely understand and appreciate the curiosity. After all, nano-hydroxyapatite is the new kid on the block! To address some of your questions and ease some of your doubts, we're answering these questions head-on...and citing scientific studies along the way.

We could talk for days about how much we love this ingredient (and why), but we know straightforward answers that reference peer-reviewed scientific sources may be a bit more useful for you.

Don't worry, we're not offended. We're ready to dive in.

is hydroxyapatite safe?

The short answer to this question is yes. Hydroxyapatite itself is a non-toxic, biocompatible mineral that already exists naturally in your body. In fact, it makes up roughly 97% of your tooth's outer surface.

Hydroxyapatite toothpaste is safe when formulated intentionally and carefully. (And we can guarantee that Davids has been formulated with the utmost intention and care.) Now, when we say that the safety of hydroxyapatite toothpaste depends on its formulation, we mean…

The size of hydroxyapatite particles matters. Nano-hydroxyapatite particles are between 20-80 nanometers, and research shows that this tiny particle size is most effective in strengthening, protecting, and supporting your teeth. Think about it this way, the erosion/damage on your teeth (enamel damage, cavities, and the tubules that can become exposed as a result) occur on a nano-level, so you'll want nano-sized particles to help!

Diligent user/lab testing matters. How can you prove the safety+efficacy of toothpaste without lab testing? We're thrilled to say that we submitted samples of the top competing sensitive toothpastes to one of the largest and most trusted third-party laboratories that specialize in oral care product testing, and Davids significantly outperformed the competing products by most effectively plugging the tubules and blocking the passageways to the nerves to support sensitive teeth.

The other ingredients in the toothpaste matter. Hydroxyapatite is an amazing ingredient, but what if it's coupled with other not-so-great ingredients? At Davids, we use the highest quality ingredients across the board. Trust us, our formula of premium ingredients took over 4 years to perfect.

does the % of hydroxyapatite in hydroxyapatite toothpaste matter?

The short answer is: it's not that simple.

You'll find that some functional dentists recommend looking for hydroxyapatite toothpaste with "at least X% of hydroxyapatite" in the formula.

But the truth is, toothpaste with 10% hydroxyapatite (no we don't use 10%) can be more effective than toothpaste with 50% hydroxyapatite. The efficacy of the toothpaste depends on so much more than the % of the hero ingredient, such as the type and grade of material being used.

what percentage of Davids Sensitive+Whitening Nano-Hydroxyapatite Toothpaste is actually nano-hydroxyapatite?

We do not disclose % as this is proprietary information to our formulation, and does not provide any meaningful info on how the toothpaste actually performs. The 3rd party lab testing we did shows that we outperformed all the leading competitive brands of hydroxyapatite toothpaste submitted and most effectively plugged the tubules to support sensitive teeth. Please visit our website to see photos as part of our lab results that show the effectiveness of our formulation.

what's the difference between hydroxyapatite, nano-hydroxyapatite (n-HA), and micro-hydroxyapatite?

Hydroxyapatite is the name of the mineral itself, and for those interested, its chemical formula is Ca10(PO4)6(OH)2. Hydroxyapatite makes up roughly 97% of your enamel, and hydroxyapatite-like compounds make up roughly 65% of your bones!

Nano-hydroxyapatite (n-HA) is hydroxyapatite with tiny particle sizes between 20-80 nanometers. Scientific studies confirm that these nanoparticles are more effective than microparticles in binding to the proteins in your saliva and, in turn, the surface of your enamel. This allows it to strengthen the surface of your tooth + plug the tubules that lead to your tooth's nerve and support sensitive teeth. This is why most toothpastes with hydroxyapatite (including Davids) utilize nano-sized particles.

Micro-hydroxyapatite particles are at least 1,000 larger than nano-hydroxyapatite particles. They are less effective in treating dental erosion/damage because they do not interact/bind as well with the cells and surfaces in your oral microbiome.

While nano-hydroxyapatite is more effective than micro, Dr. B of Ask the Dentist confirms that there are no safety concerns regarding the absorption of particles based on size. In other words, both micro and nanoparticles can (and will) be absorbed by your cells, which is not an issue because hydroxyapatite is both non-toxic and biocompatible.

For more information, we recommend listening to his podcast episode, "Does Size Matter?"

how long does it take for hydroxyapatite toothpaste to support sensitive teeth?

This study reveals that nano-hydroxyapatite toothpaste is an effective option for sensitive teeth and can provide noticeable support after 2-4 weeks of regular use.

Our third-party lab testing revealed that our unique formula was effective in bonding to your enamel and plugging the passageways to your tooth's nerve to support sensitive teeth after just five days of twice-daily brushing.

can hydroxyapatite help to reverse cavities?

Yes, because it's so effective in strengthening your enamel, hydroxyapatite can help reverse cavities and prevent new ones from forming!

Check out this article with studies compiled by Mark Burhenne, DDS (of Ask the Dentist) & Jacqueline Carcaramo, RDH. Many of the studies discuss how effective hydroxyapatite is at strengthening your teeth and reducing dental caries.

how do I know which one is the best hydroxyapatite toothpaste?

We may be biased, but our third-party lab testing results are not.

We submitted samples of the top competing sensitive toothpastes to one of the largest and most trusted third-party laboratories that specialize in oral care product testing to see how well Davids Sensitive+Whitening Nano-Hydroxyapatite toothpaste would perform against the competition.

All numerical and photo evidence from the lab results showed that Davids significantly outperformed the competing products by most effectively plugging the tubules and blocking the passageways to the nerves to support sensitive teeth. In other words, science reveals that Davids is the best toothpaste with hydroxyapatite!

Competing products include Apagard Premio, Boka, Colgate Sensitive, Risewell, Sensodyne Pronamel, and Toms Sensitive.

a collage of different types of cells

how can I use hydroxyapatite best (to maximize benefits) in my oral care routine?

Here are a few tips:

  • Brush (at least) twice daily with Davids Sensitive+Whitening Nano-Hydroxyapatite Toothpaste, as it outperforms its competitors.
  • Start right away, even if you don't have sensitivity! Like most ingredients, hydroxyapatite works best as a preventative measure. In fact, research reveals that hydroxyapatite can effectively reduce and prevent tooth decay, especially in children.
  • Enhance the health of your oral microbiome by eating a nutrient-dense diet that aids strong, healthy teeth.
  • Elevate your holistic oral care routine with daily flossing and tongue scraping.
  • Stay consistent. One of the best ways to do this is to take note of how your teeth feel once you start using nano-hydroxyapatite toothpaste.

try it out yourself!

You can continue to read our rave reviews+results as much as you want, but the proof is in the paste! Try out our revolutionary hydroxyapatite toothpaste for yourself.

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does hydroxyapatite whiten teeth? the science behind it

key takeaways: Hydroxyapatite is a mineral found in your tooth enamel and dentin, so replenishing the enamel with hydroxyapatite may help make your teeth appear whiter. Hydroxyapatite toothpaste may help brighten your teeth without irritating your gums, making it an ideal choice for those who need support for sensitive teeth. A potential benefit of hydroxyapatite toothpaste is that it can continue to whiten your teeth long-term while also helping regulate the oral microbiome. Capturing photos of life’s most exciting and meaningful events is a wonderful way to catalog your memories, but if you find yourself hesitating to share your biggest smile in them, you might be looking for options to help brighten it. If you have sensitive teeth, finding a whitening toothpaste that’s gentle on your mouth can be a challenge. Hydroxyapatite can offer a gentle, more naturally-derived option for you. Does hydroxyapatite whitening toothpaste whiten teeth, though? 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benefits of xylitol in toothpaste A dollop of xylitol toothpaste on a bamboo toothbrush.

spotlight on sweeteners: why xylitol toothpaste takes the cake

key takeaways Unlike traditional sweeteners, xylitol in toothpaste is anti-cariogenic, meaning it actively prevents decay by inducing cell death in harmful oral bacteria. While artificial sweeteners like saccharin and sucralose are purely flavorants, xylitol provides therapeutic benefits by increasing saliva flow to support natural enamel remineralization. Davids prioritizes USA-made, birch-derived xylitol to ensure non-GMO, sustainable, and high-purity ingredients. It’s hard to believe, but for much of the 19th century, dental soaps and detergents contained sugar. Scientists and manufacturers didn’t understand the link between sugar and dental health until the latter part of the century, pushing into the beginning of the 20th century. Until the discovery of this connection, manufacturers needed to mask the bitter, chemical taste of the soap. 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This discovery then drove a quest to develop a toothpaste without harmful sweeteners, or at least one with less harmful ones. In 1879, Constantin Fahlberg, while researching coal tar derivatives at Johns Hopkins University, accidentally stumbled on the non-sugar sweetener, saccharin. After synthesizing a new compound from the coal tar, he noticed a sweet taste on his hands. Upon testing it, he found it to be much sweeter than sugar. Despite the excitement around Fahlberg’s discovery, debates were contentious around the sweetener. People were concerned about long-term exposure. The debates culminated in the 1970s FDA ban proposal, which was later overturned. Today, saccharin remains a popular sweetener, especially its derivative, sodium saccharin, but it’s only one of many. Xylitol in toothpaste is quickly becoming the most popular sugar alternative because of its quality andhealth benefits. common sweeteners and their quality Saccharin isn’t the only non-sugar sweetener in the market. 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This change makes the substance non-caloric. While this all sounds nice on a surface level, it once again results in an ingredient with limited benefits other than flavor. Unlike xylitol in toothpaste, sucralose is facing increased scrutiny. Recent studies, including a 2024 PMC report, suggest that sucralose disrupts the gut microbiome, leading to dysbiosis and adversely altering the intestinal microbiota. A 2022 report in the MDPI Journal of Microorganisms also found that sucralose consumption can alter glucose and insulin levels in young healthy adults. Furthermore, the Journal of Cancer Discovery published a 2025 article linking high-dose sucralose consumption to altered immunotherapy responses in mice. Research is ongoing. The current assumptions may change, but with adverse findings culminating, sucralose may join sugar in the harmful sweeteners category. sorbitol Moving on to sugar alcohols, we have sorbitol. For toothpaste without harmful sweeteners, it’s the most common sugar alcohol. It’s present as a polyol in fruits, but is often commercially manufactured from corn syrup. In toothpaste, sorbitol acts as a mild sweetener (about 60% as sweet as sugar) and a humectant, a substance used to promote moisture retention. Unlike xylitol in toothpaste, which is entirely non-fermentable, sorbitol is fermentable to some oral bacteria, meaning it’s a low-cariogenic substance. Despite this low fermentability, sorbitol still reduces bacterial counts compared to sugar, although less effectively than xylitol (44.1% compared to 64.4% over a week). This means sorbitol doesn’t actively cause cavities, but it also means it doesn’t actively prevent them. A recent and alarming 2025 study published in Science Signaling suggests a possible connection between sorbitol and liver health. For most people, the gut microbiome contains a sorbitol-degrading bacterium, which allows the sorbitol to pass through the system. The study suggests that in people without this bacterium, sorbitol may pass undigested to the liver, converting to fructose derivatives and contributing to liver disease. xylitol That brings us to xylitol in toothpaste, the current favorite of the sweeteners and sugar alcohols. Unlike the other sweeteners on this list, xylitol is anti-cariogenic, which means it actively prevents decay. While other sweeteners are unattractive to harmful bacteria as a fuel source, xylitol mimics sugar properties, motivating bacteria (Streptococcus mutans) to ingest it. The bacterium doesn’t have the enzymes to ferment xylitol for energy, so it relies on its existing energy stores, resulting in an energy cycle that hastens toward cell death. Beyond its antimicrobial mechanism, xylitol reduces bacterial and plaque adhesion properties. This makes it easier to eliminate both with routine brushing. Also, xylitol in toothpaste supports mineral transport by increasing saliva production, supporting remineralization. For extra support in a toothpaste without pure sweeteners like sugar, Davids pairs xylitol withnano hydroxyapatite, a mineral-rich ingredient. The xylitol helps maintain a neutral pH in the mouth, allowing the minerals to bond with the enamel tooth surface. Davids birch-derived xylitol for pure quality Davids commitment to premium quality, environmental sustainability, and consumer trust drives our business model and ingredient choices. We could choose a corn-based xylitol source to save money and production costs, but that would expose our consumers to GMO risks and reduce our high-quality standards. That’s why we use birch-derived xylitol instead. Our birch-derived xylitol for toothpaste not only supports local economies but also ensures a transparent and traceable supply chain. It also results in a purer ingredient and a cleaner sensory profile that is non-GMO defensible. Are you ready to experience the Davids difference? Shop our selection of clean, pure toothpaste today. frequently asked questions How much xylitol should you use daily for the best oral health results? The specific amount for oral health depends on individual needs. However, the consensus is a total of 5 to 10 grams divided into three doses daily for dental caries prevention. These doses can come from xylitol in toothpaste, lozenges, gum, or syrups. Is xylitol okay for people with diabetes? Xylitol is an excellent option, especially for people seeking a toothpaste without sweeteners like sugar. It has a low Glycemic Index (GI) score of 7 and only has 2.4 calories per gram. Comparatively, sugar has a GI score of 60 and 4 calories per gram. The lower score and calorie count mean xylitol may be a preferable alternative for those managing insulin levels.

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